Endocrine Abstracts

Due to remarkable improvements in treatment and supportive care over the past several decades, survival rates for childhood cancer currently exceed 85%. Nevertheless, survivors exposed to cranial radiotherapy (CRT) are at particularly high risk for long-term morbidity, such as endocrine insufficiencies, metabolic complications and cardiovascular morbidity. Research report that 40-50% of survivors will develop an endocrine disorder over their lifetime. Deficiencies of one or mo...

Survival rates of childhood cancer have improved markedly and today more than 80% of those diagnosed with a pediatric malignancy will become 5-year survivors. Nevertheless, survivors exposed to cranial radiotherapy (CRT) are at particularly high risk for long-term morbidity, such as endocrine insufficiencies, metabolic complications and cardiovascular morbidity. Deficiencies of one or more anterior pituitary hormones have been described following therapeutic CRT for primary br...

Introduction: Acute lymphoblastic leukaemia (ALL) is the most common childhood malignancy and accounts for 25% of all childhood cancer. With dramatically improved survival rates the long term treatment complications are very important. ALL patients treated with cranial radiotherapy (CRT) and chemotherapy are at increased risk of GH deficiency (GHD), hyperparathyroidism, thyroid cancer and meningiomas.Method: We present a 45-year-old woman diagnosed with ...

Survivors of childhood (CO) ALL treated with prophylactic cranial radiotherapy (CRT) often exhibit (GHD) and increased cardiovascular risk. The aim of this study was to evaluate the effect of 4 years of GH therapy on cardiovascular risk factors in 16 former ALL patients and to compare them with matched population controls after 4 years.Sixteen former CO ALL patients (women=8), aged 24–37 years, treated with CRT (18–24 Gy) and chemotherapy with ...

Background: Survival rate after childhood cancer has improved markedly and today more than 80% of patients with a pediatric malignancy will become 5-year survivor. During the past years it has become evident that many childhood cancer survivors suffer from late complications due to the radiotherapy and chemotherapy. It is established that the largest childhood cancer group, the acute lymphoblastic leukemia (ALL) survivors, exposed to cranial radiotherapy are at particularly hi...

Background: Survivors of childhood leukaemia (ALL) treated with cranial radiotherapy (CRT) are at risk for cognitive impairment. Whether the impairment progresses with follow-up time and if survivors with cognitive impairment have an increased risk for overweight, is unknown. We aimed to investigate the long-term cognitive functioning in ALL survivors treated with CRT in comparison to matched controls.Method: Cognitive functioning was investigated in 38 ...

Background: Previously, the endocrine nurses in Sweden, Denmark, Norway, Finland and Iceland have not been organized. As Endocrine nursing is specialized and no education for a specialist competence in endocrinology is available there is a need for a collaboration to improve the Nordic endocrine nursing.Purpose: The purpose of the Nordic network for endocrine nurses (NNEN) is to enhance the Nordic endocrine nurse knowledge and skills, and also work for a...

Context: Acute lymphoblastic leukaemia (ALL) is the most common pediatric malignancy and its treatment includes many known risk factors for low bone mineral density (BMD), e.g. glucocorticosteroids, methotrexat and cranial radiotherapy (CRT).Objective: To evaluate bone mineral density (BMD) and markers of bone turn over in a group of adults with childhood onset ALL, treated with CRT and to evaluate the effect of 5 years with, and 8 years without GH thera...

Background: Metabolic complications with obesity are frequent in childhood acute lymphoblastic leukemia (ALL) survivors treated with cranial radiotherapy (CRT). Childhood onset Craniopharyngioma (CP) survivors without hypothalamic (HT) involvement are spared gross obesity. Magnetic resonance diffusion tensor imaging (DTI) provides information of microstructure function of the brain and quantified as fractional anisotrophy (FA), mean diffusivity (MD), axial and radial diffusivi...

Background: Metabolic complications (obesity, lipid abnormalities, and insulin resistance) are prevalent in acute lymphoblastic leukemia (ALL) survivors treated with cranial radiotherapy (CRT). The hypothalamus (HT) is a complex area involved in endocrine function and metabolic control. In ALL survivors, assessment of the volume of the HT in relation to metabolic parameters including ghrelin, a peptide stimulating food intake, has not been performed previously.<p class="ab...